As the curtain falls on an incredible year, we at SPT Labtech pause to celebrate the remarkable achievements of 2024. This year has been defined by innovation, teamwork, and progress, bringing us closer to transforming the landscape of life...
As we bid farewell to a remarkable year, we at SPT Labtech take a moment to reflect on the extraordinary strides we've made in 2023. It's been a year of innovation, collaboration, and advancement, marking significant milestones in our journey...
As cryo-EM adoption has grown so has the demand to prepare specimen using conventional commercial instruments and DIY set ups. However, most samples exhibit non-ideal behavior and the resulting specimen rarely achieve the reproducible and...
Sample preservation in vitrified ice (vitrification) is widely acknowledged as the first step in the cryogenic electron microscopy (Cryo-EM) workflow. However, prior to sample preparation researchers must consider the sample quality and determine...
The period responsible for the current generation of cryogenic electron microscopy (cryo-EM) instrumentation and image processing software is often referred to as the “resolution revolution.” The results of these technological advancements have been...
The preparation of acceptable frozen-hydrated samples on transmission electron microscopy (TEM) grids is well known to be a challenging bottleneck in the cryogenic electron microscopy (cryo-EM) workflow. During sample vitrification it is assumed...
The recent COVID-19 global pandemic has unleashed a massive global response to develop therapeutic treatments for those suffering from COVID-19 and a vaccine against the SARS-CoV-2 virus. Structural biologists from all over the world have mobilized...
Just when you think you’ve discovered everything there is to know about a subject and there’s little left to learn or discover, something comes out of nowhere to prove you wrong! But in crystallography that’s not necessarily a bad thing…
Obtaining detailed structures of any membrane protein has been challenging. A detergent is required to extract the protein from the lipid environment which does not contribute to a favorable environment for crystallization using traditional vapor...
Most drugs bind to a target’s binding site (orthosteric binding). However, binding to a site distant from the binding site appears to have some very significant advantages over orthosteric binding, one of which is reducing off-target side-effects.
Membrane proteins serve a number of vital roles in the body, including oxygen production, transport of nutrients into cells, transport of water into and out of cells, removal of waste products, and allowing information to enter cells. Thirty percent...