Resources

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Advancing 3D Cell Culture: Automated positive displacement dispensing of MCF7 and HepG2 cells, mixed with PeptiMatrix™ Hydrogel

In vitro cell cultures are essential for modelling disease, but traditional 2D cell culture systems fall short in replicating the complex microenvironments of native tissues. This limitation hinders the translation of in vitro findings to in vivo contexts and contributes to the high attrition rates seen in drug discovery pipelines.

Application note

Webinar recording: Automated sample management for more efficient drug discovery: Developing and embedding in-house sample management at Artios

In this webinar, learn how the team at Artios Pharma have developed and implemented automated end-to-end workflows for sample storage and tracking, processing, assay-ready plate generation and sample mapping for analysis, using Titian Sample Bank software and SPT Labtech automation systems. Using this compound management workflow, they have demonstrated up to a 40% reduction in data posting cycle times and decreased running costs, as well as using the system for clinical sample supply and tracking, all of which results in quicker data reporting to drive decision making and more effective use of resources.

Webinar

High-throughput endometrial organoid plating in Matrigel using SPT Labtech's firefly®

Organoids are biologically complex three-dimensional structures that provide physiologically relevant models for studying multifaceted phenomena, such as disease progression, embryonic development, and drug response. The use of organoids has been steadily increasing and triggers the demand for reliable and scalable workflows for their generation and culture. Organoids typically require a supportive matrix that facilitates the formation of three-dimensional structures and sustains their proliferation.

Application note

Efficient Long-Read Genome Library Prep in the Wellcome Sanger Institute’s Darwin Tree of Life Project

Presenting the successful automation of a long-read whole genome library preparation using the PacBio SMRTbell long-read prep kit 3.0 (SPK3) on SPT Labtech's firefly liquid handling platform.

Webinar

BioMicroLab XL9 & XL20 Tube Handling Systems Brochure

The XL9 & XL20 are reliable, flexible and affordable robotic pick and place systems used to automate critical sample management tasks such as organizing, reformatting and accurately tracking samples. The XL9 and XL20 are fully compatible with LIMS systems and with multiple labware formats. Choose and order your XL Series platform with the capacity and modules right for your lab’s application.

Brochure

Automating antibiotic discovery in academia: A collaborative screening effort to identify novel TB therapeutics

In this webinar, hear how a collaboration between SPT Labtech, Automata, GSK, and researchers at the Francis Crick Institute, employed cutting-edge automation tools, including the dragonfly® discovery liquid handling system by SPT Labtech and Automata’s LINQ platform, to conduct a high-throughput enzymatic screen targeting a vulnerable pathway in Mycobacterium tuberculosis (Mtb).

Webinar

An introduction to mosquito Gen3 - Product Overview

Introducing our most compact and accessible member of the mosquito family. mosquito Gen3 offers highly accurate and precise multi-channel pipetting from 500 nL to 5 µL, allowing genomics researchers to benefit from miniaturization across a range of applications, irrespective of liquid class. The instrument’s rapid plate-to-plate pipetting motion and tip exchange maximize speed and efficiency.

Video

Automating NEBNext® UltraExpress® NGS Library Prep with SPT Labtech’s firefly® for rapid, high-throughput NGS library generation at Harvard Medical School’s core facility

We demonstrate the ease of automating NEB’s UltraExpress® kits with the user-friendly firefly® system, achieving high-quality and reproducible libraries and sequencing data. Libraries were prepared from 25ng to 250ng of total RNA, consistently showing high data quality across this input range.

Poster

High-throughput single cell DNA methylation coupled with true positive displacement liquid handling technology enables epigenetic profiling of thousands of single cells

In this study, we explore the benefits of automating the Scale Bio single cell methylation protocol with SPT Labtech’s firefly® to facilitate the analysis of single cell methylomes isolated from human peripheral blood mononuclear cells (PBMCs) compared to a library prepared in parallel using manual methods.

Poster

Designing the future of cultivated meat: An Uncommon journey to cost-effective stem cell growth media

Cellular agriculture could be instrumental to environmentally-friendly food production. However, high raw materials costs impede financial viability. This poster highlights how the team at Uncommon have applied automated liquid handling and Design of Experiment (DoE) methodology to drive the development of low-cost, animal-free media.

Poster

Automating PacBio library construction: Scaling the Darwin Tree of Life project at the Wellcome Sanger Institute

The DToL initiative aims to advance our understanding of life on Earth by unravelling the genetic blueprintt of a wide range of organisms. To address the scale of this challenge, the team at the WSI describe the development and validation of a novel automated method on firefly® to construct whole genome sequencing libraries from genomic DNA using the PacBio SMRTbell prep kit 3.0.

Poster

Enhancing drug safety evaluations with automated liquid handling: Introducing the ICESTP Safety Panel 90 for functional and dose-response screening in secondary pharmacology

The ICESTP Safety Panel 90 includes 138 assays, incorporating both single-point screening and dose-response screening with a functional assay format, such as Automatic patch clamp, FLIPR calcium flow, and HTRF, for example. In this poster, we demonstrate the use of SPT Labtech’s firefly® automated liquid handling platform for high-throughput sample processing to facilitate the safety assessment of a 90-target panel, to improve the efficiency and accuracy of drug safety evaluations.

Poster

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