Resources

Explore insightful resources that include videos, whitepapers, eBooks, application notes and more

Automating antibiotic discovery in academia: A collaborative screening effort to identify novel TB therapeutics

In this webinar, hear how a collaboration between SPT Labtech, Automata, GSK, and researchers at the Francis Crick Institute, employed cutting-edge automation tools, including the dragonfly® discovery liquid handling system by SPT Labtech and Automata’s LINQ platform, to conduct a high-throughput enzymatic screen targeting a vulnerable pathway in Mycobacterium tuberculosis (Mtb).

Webinar

An introduction to mosquito Gen3 - Product Overview

Introducing our most compact and accessible member of the mosquito family. mosquito Gen3 offers highly accurate and precise multi-channel pipetting from 500 nL to 5 µL, allowing genomics researchers to benefit from miniaturization across a range of applications, irrespective of liquid class. The instrument’s rapid plate-to-plate pipetting motion and tip exchange maximize speed and efficiency.

Video

Automating NEBNext® UltraExpress® NGS Library Prep with SPT Labtech’s firefly® for rapid, high-throughput NGS library generation at Harvard Medical School’s core facility

We demonstrate the ease of automating NEB’s UltraExpress® kits with the user-friendly firefly® system, achieving high-quality and reproducible libraries and sequencing data. Libraries were prepared from 25ng to 250ng of total RNA, consistently showing high data quality across this input range.

Poster

High-throughput single cell DNA methylation coupled with true positive displacement liquid handling technology enables epigenetic profiling of thousands of single cells

In this study, we explore the benefits of automating the Scale Bio single cell methylation protocol with SPT Labtech’s firefly® to facilitate the analysis of single cell methylomes isolated from human peripheral blood mononuclear cells (PBMCs) compared to a library prepared in parallel using manual methods.

Poster

Designing the future of cultivated meat: An Uncommon journey to cost-effective stem cell growth media

Cellular agriculture could be instrumental to environmentally-friendly food production. However, high raw materials costs impede financial viability. This poster highlights how the team at Uncommon have applied automated liquid handling and Design of Experiment (DoE) methodology to drive the development of low-cost, animal-free media.

Poster

Automating PacBio library construction: Scaling the Darwin Tree of Life project at the Wellcome Sanger Institute

The DToL initiative aims to advance our understanding of life on Earth by unravelling the genetic blueprintt of a wide range of organisms. To address the scale of this challenge, the team at the WSI describe the development and validation of a novel automated method on firefly® to construct whole genome sequencing libraries from genomic DNA using the PacBio SMRTbell prep kit 3.0.

Poster

Enhancing drug safety evaluations with automated liquid handling: Introducing the ICESTP Safety Panel 90 for functional and dose-response screening in secondary pharmacology

The ICESTP Safety Panel 90 includes 138 assays, incorporating both single-point screening and dose-response screening with a functional assay format, such as Automatic patch clamp, FLIPR calcium flow, and HTRF, for example. In this poster, we demonstrate the use of SPT Labtech’s firefly® automated liquid handling platform for high-throughput sample processing to facilitate the safety assessment of a 90-target panel, to improve the efficiency and accuracy of drug safety evaluations.

Poster

Miniaturized Illumina Nextera XT library preparation on mosquito® to support high-throughput sequencing services

This application note highlights how mosquito HV genomics has been used to automate the Illumina Nextera XT protocol at SEQ-IT, achieving 5X miniaturized reaction volumes while delivering reproducible, high-quality libraries. Based in Kaiserslautern in Germany, SEQ-IT is a mid-sized company offering both Sanger sequencing and NGS services.

Application note

Achieving cost-effective NGS through automated miniaturization of Illumina Nextera XT library preparation

This poster highlights how mosquito HV genomics has been used to automate the Illumina Nextera XT protocol at SEQ-IT, achieving 5X miniaturized reaction volumes while delivering reproducible, high-quality libraries. This miniaturized method was developed to identify and screen mutations with oncogenic potential and drug resistance (HIV, HBV, HCV), SNP detection, as well as in HLA-typing, among other applications.

Poster

Developing and Embedding In-House Compound Management within Artios

Using dedicated software and automation, Artios have developed in-house compound management for Design-Make-Test-Analyze processing and assay-ready plate generation. This results in: - Increased sample and data integrity through audited and trackable processes - Reduced cycle times and cost - Faster data reporting for better decision making and use of resources

Poster

Streamlined library preparation with enzymatic fragmentation: Automating KAPA EvoPlus V2 Kits on firefly®

We demonstrate that the Roche KAPA EvoPlus V2 and KAPA EvoPlus V2 PCR-free DNA library preparation workflows can be successfully automated on firefly to create Illumina-compatible NGS libraries comparable to those prepared manually. The combination of these technologies enables significant time savings in the laboratory for whole genome sequencing applications, whilst also reducing operator variability.

Poster

Advancing in vitro high-throughput transcriptomics for chemical toxicity testing | SPT Labtech

Hear from researchers from McGill University, as they present case studies in optimizing and advancing efficient workflows that couple in vitro exposures with ultraplexed library preparation using the QIAseq UPXome RNA Library Kit. This approach has increased the throughput of differential expression and dose-response analysis for tPODs derivation.

Webinar

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