Resources

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dragonfly

Optimizing multi-cellular models for high-throughput screening - Webinar

Join us as we dive into recent research which has combined Design of Experiments methodology with automated liquid handling to develop a cardiotoxicity assay platform. We discuss how this approach could become routine in the future, not only offering more accurate predictability of new drug candidates, but also enabling researchers to leverage resources more efficiently through streamlined workflows and data-driven decision-making.

Webinar

Transforming PCR protocols in pandemic response with automated non-contact liquid dispensing

The UK’s first testing “megalab”, the Rosalind Franklin Laboratory (RFL) in Royal Leamington Spa, was established in 2021 with the aim of processing and sequencing thousands of COVID-19 tests a week, playing a key role in preventing disease outbreaks and responding to new variants of concern and future disease threats. With the critical need for accurate pathogen surveillance, the manual execution of PCR workflows emerged as a bottleneck, limiting throughput and introducing potential for human error and variability among lab personnel. To enhance efficiency and data quality, the lab chose to adopt dragonfly® discovery to improve the accuracy and reliability of extraction plate preparation for the UltraDX SARS-CoV-2 N1/N2/RP assay (LGC, Biosearch Technologies).

Poster

dragonfly discovery technical note: PCR reaction set-up by dragonfly®

A vast number of advantages can be gained by semi-automating genomics workflows through use of low volume liquid handling instruments, such the mosquito® genomics and dragonfly® discovery offered by SPT Labtech. Benefits include the miniaturization of reaction volumes to reduce cost per sample and the elimination of most sources of human error to increase experimental reproducibility. In this technical note we have tested the effect of mixing on cross-contamination between different wells during PCR set-up.

Technical note

dragonfly® discovery: Pioneering Sustainable Liquid Handling in the Modern Laboratory

In this poster, we highlight the significant role that dragonfly discovery plays in reducing the environmental impact of liquid handling workflows. In our first case study, dragonfly discovery demonstrates a reduction in plastic pipette tip usage by over 99% compared to traditional air displacement pipetting systems when performing a 3456-run enzymatic assay operated by 6-factor space-filling Design of Experiment (DoE). In Next-Generation Sequencing (NGS) library preparation workflows, such as the NEBNext® Ultra™ II FS DNA Library prep kit presented in our second case study, dragonfly discovery achieves a plastic reduction of over 50%.

Poster

Transforming PCR protocols in pandemic response with automated non-contact liquid dispensing

During the COVID-19 pandemic, robust polymerase chain reaction (PCR) workflows were required to detect the Novel Coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2) virus in clinical samples. Accurate detection of the virus in clinical samples allowed for rapid infection containment and subsequently alleviated the pressure on healthcare services during this time. Automation of these workflows has the benefit of not only increasing throughput, but also minimizing variability and human error particularly when dealing with precious reagents and limited sample. This application note describes the process by which the UKHSA testing megalab, the Rosalind Franklin laboratory, transitioned from the manufacturer recommended extraction plate preparation workflow for an ePCR/MAGMAX MVPII, to an automated workflow using SPT Labtech’s non-contact reagent dispenser, dragonfly® discovery, resulting in an 80-fold increase in the sensitivity of the assay.

Application note

High-throughput bacterial isolation and culture using dragonfly® discovery for rapid single-cell dispensing in 384-well molten agar plates

We aim to perform high-throughput culturomics analysis of the vaginal microbiome with the goal of developing live biotherapeutics that modulate the composition and function of the vaginal microbiome to improve women’s gynecological and obstetric health. To achieve this, we need to better understand the intra-species diversity of the beneficial bacterium, Lactobacillus crispatus, and perform in-depth within-sample cultivation to obtain co-resident L. crispatus strains.

Application note

Streamline your liquid handling with scalable, integrated automation - Webinar Recording

Bringing together individual processes into an orchestrated workflow allows you to take a step further. It not only maximizes walk-away time but also fortifies your laboratory with flexible and scalable integrated workflows, ensuring seamless, end-to-end automation that aligns with the diverse needs of both budding biotech startups and established enterprise-level pharmaceutical organizations. In this webinar, experts from SPT Labtech and Biosero will share their specialist knowledge, first exploring the business benefits of combining these powerful technologies. We’ll then take a deeper dive into the practical considerations of implementing integration, sharing insights to give you the highest chance of success.

Webinar

The Future Is Here: Precision Automation Demonstrates Its Value as a Tool for Accelerating Drug Discovery

With more than 70 FDA-approved small molecules ,kinase inhibition continues to attract significant investment. Identification and characterization of novel inhibitors is a challenging, yet critical task which sets the tone for future successes and failures. Traditional single shot approaches do not meet current requirements for machine learning and carry significant risks of false negatives. Hit profiling has evolved this concept, generating potency estimates, reducing risks while providing contextual confidence. Accurate hit identification followed by high resolution, kinetic molecular profiling enhances outcomes ensuring better data-driven decision-making earlier in the process, saving time and resources, leading to superior molecular design.

Poster

SLAS 2023 Interview - Chris Waddling - dynamic duo

Discover how genomics researchers can miniaturize NGS methods to increase throughput and lower costs using the combination of the mosquito® and dragonfly® automated liquid handlers from SPT Labtech in this interview with Field Application Scientist, Chris Waddling.

Video

Accurate, miniaturized DNA quantification assays with positive displacement liquid handlers

Quantification and subsequent normalization of nucleic acids are critical steps in many genomics applications. Conventional quantification workflows use high volumes of costly reagents and waste valuable DNA. Furthermore, highly viscous DNA samples pose a challenge for automated liquid handling. Significant increases in throughput together with reduced reagent costs and sample saving can be achieved using the combination of a mosquito® pipetting robot and a dragonfly® discovery dispenser.

Application note

Supercharge your Olink workflow with the right liquid handling tools

In this webinar, discover how to maximize volumetric precision in Olink proteomic technology workflows for improved accuracy and reliability with multi-omic pipelines for full suite service providers. We will discuss how miniaturized liquid handling, enabled by dragonfly® discovery and mosquito® instruments, facilitates high-plex, precise, and repeatable proteomic profiling, supporting exploratory and pre-clinical experiments at Azenta Life Sciences. Insightful process design, in tandem with truly differentiating positive displacement volumetric technologies, enables leading labs to retain flexibility and seamlessly incorporate complex workflows demanding high precision and accuracy. Key learning objectives Understand the value of positive displacement technologies for effective multi-omics assay miniaturization Discover the benefits of incorporating Olink protein profiling technology as an expansion from genomic services into multi-omics Learn more about the practical considerations and applications of performing the Olink assay

Webinar

Miniaturizing and Automating SARS-CoV-2 Sequencing in an Epidemiological Lab

The SARS-CoV-2 pandemic required an exponential increase in the sequencing capacities of epidemiological laboratories monitoring the virus. In this webinar, Quentin Semanas and Richard Chalvignac of Hospices Civils de Lyon will discuss the miniaturization and automation of SARS-CoV-2 sequencing in their lab. Their protocol has made it possible to multiply sample processing capacity by 52 percent, allowing them to sequence up to 5,000 samples per week in the epidemic peak phases. Webinar topics: High-throughput sequencing linked to automation Significant cost reduction Simplicity and efficiency of the automated process

Webinar

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