mosquito^® LCP

Automated membrane protein screening, optimization, and scale-up to empower better protein crystallization research.

Accurate, reproducible automation for liquid cubic phase (LCP) setups

mosquito LCP for membrane protein crystallization enables accurate, reproducible automation for liquid cubic phase (LCP) setups.

The innovative positive displacement technology overcomes the common problems encountered with accurately dispensing the highly viscous LCP materials. Automated calibration of syringe and pipette positioning ensures precise drop-on-drop placement for easy automated imaging.

mosquito LCP includes all the functionality of mosquito crystal for automated vapor diffusion setups, allowing researchers to set up both LCP and traditional protein crystallization experiments in any commercially available plate, using a single instrument.

Dispense lipidic cubic phase (LCP) volumes as low as 25 nL

mosquito LCP unlocks the benefits of miniaturization, enabling researchers to use smaller volumes of protein sample and reduce screen consumption to realize substantial cost savings.

Walk up and use technology

Even novice users master the use of the mosquito LCP quickly, minimizing setup time and increasing productivity. The intuitive touch screen application-driven software and quick and easy experimental guides for rapid setup streamline the overall user experience.

True positive displacement pipetting delivers exceptional accuracy

mosquito LCP harnesses innovative positive displacement pipetting by using disposable micropipettes with individual pistons to deliver exceptional accuracy and precision, irrespective of liquid class.

Track record of reliability

Robust day-to-day performance with no blocking or clogging maximizes uptime, and safeguards research outcomes.

Simplify set up of crystallization methods

Benefit from the ability to set up both LCP and all traditional protein crystallization experiments with a single instrument using commercially available SBS format plates.

Precise humidity control improves consistency

mosquito’s active humidity chamber increases quality by reducing experimental inconsistencies caused by variation in environmental humidity.

High performance technology

Our liquid handling instruments harness innovative technology to streamline workflows and accelerate research.

Robust, reliable, and easy to use, our products overcome tough technical challenges and enable researchers to focus on the best science.

True positive displacement pipetting

Each of our disposable micropipettes has its own individual piston, not an air gap or system liquid, offering true positive displacement pipetting with no risk of cross-contamination.

Precise humidity control at your fingertips with up to a 90% reduction in drop evaporation

Sample evaporation can be a problem when dispensing very low volumes or volatile samples, causing inconsistent drop volumes, especially when environmental conditions and local humidity vary. mosquito’s precise humidity chamber reduces experimental inconsistencies by allowing users to robustly control the relative humidity of each experimen

Intuitive by design

Our application led software for protein crystallography combines usability and functionality, with an intuitive user experience tailored to each scientific application. Through collaboration with scientists, our software team develops and enhances the instrument UI to provide the optimal user experience and facilitate adoption into novel application areas.

Enhance protein crystallization research capabilities

Additional components such as a humidity chamber and an automated mixer for preparing LCP enhance the instrument’s capabilities. mosquito integrates seamlessly with a wide variety of laboratory instrumentation, including robotic plate handlers, stackers and bulk liquid handlers.

Technical Specification

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Pipetting range	25 nL - 1.2 µL	Throughput	2 minutes/ standard 96-well plate 4 minutes/ 96-well LCP plate
Primary SBS plate formats	48, 96 and 384	Accessories	Active humidity chamber, spool cover and LCP mixer
Weight	34 kg (75 lbs)	Dimensions (W x D x H)	440 mm (790 mm 4 plate deck) x 470 mm x 690 mm 17.3 in (31 in 4 plate deck) x 18.5 in x 27 in
Technical variants	2 or 4 plate position deck

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